CBD or cannabidiol is deprived of psychoactive properties, but it helps with various diseases
Recently, the main topics medical marijuana has been surfacing more and more frequently in foreign media, scientists are trying their finest to have permissions and funding for research of this type, believing in its promise, and in lots of countries of the planet, decriminalization and legalization are underway.
Most hype now causes a substance such as for instance CBD or cannabidiol included in the hemp plant. Today it can be found anywhere – from food to decorative cosmetics and quite legally purchased cbd gummies for pain uk in internet vendors in the proper execution of oil. And all because CBD does not need psychoactive properties, unlike tetrahydrocannabinol (THC), but it’s healing properties.
Since CBD is a dynamic part of marijuana itself, you may get make money from it by smoking a shared in the old fashioned way. The main thing would be to make sure that a quality with a predominance of this specific substance, rather than THC, is clogged in your joint if you would like to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to manage paranoia.
Let’s attempt to figure out how this magical cannabidiol works, on the basis of the latest data from the planet of science and the ability of consumers using CBD as a medicine, and not for fun.
The difference between the effects of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high from it, but it’s easy to improve your productivity, relieve anxiety and relieve pain. When working with CBD, thoughts aren’t confused, memory doesn’t deteriorate, and consequently of muscle relaxation, you don’t become a vegetable, as is usually the case with smoking cannabis varieties with a predominance of THC.
If the ratio of those substances is approximately the same, then you may find a small euphoric and the above-mentioned beneficial effects at the same time. At the same time, such negative consequences as paranoia, dry mouth, drying out and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are generally due to THC, do not occur. Such varieties are most often used as a painkiller.
Although CBD works well alone, some experts still insist that in conjunction with other active aspects of marijuana, it brings more benefits:
“To attain a better therapeutic effect, you will need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, to start with, by deficiencies in research data, since the field of studying the healing properties of hemp continues to be in its infancy. But the gradual legalization of medical marijuana implies that scientists will soon do have more freedom for their experiments. So contain the fists, hope and believe.
What diseases cannabidiol helps to cope with
Some scientific papers claim that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope this substance can help pharmaceutical companies to develop effective drugs against many disorders and diseases followed closely by similar symptoms.
The set of such diseases includes, but isn’t restricted to such pathological conditions:
So far, you will find no full-fledged drugs predicated on CBD to combat these disorders, but many patients claim that the substance helps them to ease and even completely get rid of the symptoms.
Recently in the USA, where marijuana continues to be on the list of the most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the very first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of that the FDA has confirmed with its tests. Today, Epidiolex can be used to deal with severe types of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there have been other drugs on the basis of the aspects of marijuana. For instance, the Belgian company Solvay Pharmaceuticals in 1985 created Marinol (dronabinol), a medication that is simply an artificial THC, that will be still used today to improve the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal parts of CBD and THC, to ease muscle cramps and other apparent symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there’s still less data how CBD has a beneficial effect on the body, scientists still possess some ideas with this subject. Surprisingly, cannabidiol doesn’t bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the same THC. Nonetheless it interacts with the GPR55 protein secreted in the mind and peripheral organs. Researchers believe this determines its antispasmodic effect.
In the mind, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted from one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more frequently than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, in accordance with Ben Wally, head of research at GW Pharmaceuticals.
The partnership of the protein with CBD is confirmed by experiments with genetically modified rodents by which epileptic seizures were caused. Those animals by which GPR55 was present responded to cannabidiol treatment, and rats without protein continued to have convulsions.
Wally also believes that CBD can donate to the desensitization of the TRPV1 protein, that will be active in the transport of ions and calcium in the body, which also helps relieve cramping. First, cannabidiol activates this protein, but quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not answer CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance created by the body. Wally believes that cannabidiol suppresses seizures, mainly due to its effect on adenosine, but more experiments are essential to confirm this hypothesis.
Such a wide selection of areas by which CBD is active allows scientists to suggest this substance might be useful in the treating motor disorders, such as for instance Parkinson’s disease. And the interaction with serotonin receptors implies that cannabidiol may be used to deal with depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for instance Roger Pertwee, a professor at the University of Aberdeen and the head of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it can not be confidently stated that the interaction of CBD with these receptors and proteins means so it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we provides you with a set of popular cannabidiol-dominated varieties so you know what to ask about next time in your telegram supermarket: